By number, identify all of the following four statements regarding energy systems that are true: 1) Aerobic and anaerobic distinction is made depending on whether carbon dioxide is produced in the production of energy; 2) Both aerobic and anaerobic energy systems use substrate phosphorylation to synthesize ATP; 3) Energy systems differ from each other with respect to the rate and the duration of energy production; 4) Lactic acid is produced during energy production by the high energy phosphate system.